Yes, absolutely. You just need to make your data collection items (DCIs) in a template. The you would apply the template to the node (you can select container when applying, in this case template would be applied to all nodes under that container).

It's also possible to automate template application - you can check in out-of-the-box templates, e.g. Operating Systems -> Windows - in properties of it there's Automatic Apply Rules.

Also, we've recently published a half-hour long recording of NetXMS Demo session - this might be helpful to see what are the capabilities of the system:
https://www.youtube.com/watch?v=QhHznyOXEFk